
Dr. Mario 64 is a puzzle game based on the original Dr. Mario. It was developed by Newcome and published by Nintendo, released for the Nintendo 64 in 2001, and is an enhanced remake of the original Dr. Mario, which was released for the NES and Game Boy in 1990.
It was re-released along with Panel de Pon and Yoshi’s Cookie in a GameCube video game called Nintendo Puzzle Collection in 2003, which was only released in Japan.
Dr. Mario 64 plays the same as its predecessors for the most part. Dr. Mario throws Megavitamins into a jar full of Viruses, and lining up a combination of Viruses and Megavitamins (four at minimum), they disappear. There are three types of Viruses – the Red Virus (Fever), the Blue Virus (Chill) and the Yellow Virus (Weird), with a Megavitamin color designed to kill them. It includes the main songs from the original Dr. Mario, Fever and Chill, but it also includes two new songs called Cube and Que Que.
Dr. Mario 64 features many different modes of play. The first one is “Classic mode”, which features a similar set-up and design to earlier Dr. Mario video games. The second mode of play is called “Story mode”. In it, the player may take control of either Dr. Mario or Wario to track down the stolen Megavitamins, battling computer players on the way. Dr. Mario 64 also features a mode where the player may battle against the computer as any character the player has played as or fought against. Up to four players may play Dr. Mario 64 at once in the Multiplayer mode, which is designed similarly to the CPU VS. mode.
Dr. Mario 64 features a mode called “Flash mode”, where the player must focus on clearing flashing viruses. Also included is a “Marathon mode”, which consists of a never-ending rising field of viruses. This mode does not end until the player quits or loses. Another mode is the “Score Attack mode”, where the player is given three minutes to clear all of the viruses as well as get a high score.

| Developer(s) | Newcome |
| Publisher(s) | Nintendo |
| Platform(s) | Nintendo 64, iQue Player |
| Release date(s) | USA April 9, 2001 CHN November, 2003 (iQue) |
| Genre(s) | Puzzle game |
| Mode(s) | Single player, multiplayer |
| Rating(s) | ESRB: Everyone |
| Media | Cartridge |



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