
Dr. Mario (Dr. マリオ?) is an arcade-style puzzle video game produced by Nintendo. It was originally released for the Nintendo Entertainment System and Game Boy in 1990. Its play mechanics are compared to Tetris. In this game, Dr. Mario throws vitamins that the player must align in order to destroy the viruses that populate the playing field (designed to resemble a medicine bottle).
U.S. Patent 5,265,888 covers Dr. Mario, but as of 2004, Nintendo has not enforced it against amateur software developers.
A puzzle game similar to Tetris, Dr. Mario features Nintendo mascot Mario as a doctor. Gameplay consists of dropping two-sided vitamin capsules into an eight-block-by-16-block playing field populated by viruses of three colors (red, yellow, and blue).
There are six types of capsules, each one being a combination of two of the three possible colors. The player must rotate and position these capsules on top of and alongside the viruses and other capsules in an effort to eliminate the viruses. Both viruses and capsules are eliminated when four or more objects of corresponding color are placed in a row or column. A player completes a level by eliminating all viruses on the playing field. The game will end if any capsules obstruct the bottle’s narrow neck at the top row of the field.
When the game is first started, a selection board is shown with several options to modify: level, speed, and music. The player can start at any one of 21 distinct levels (0-20), with levels up to 40 accessible by those who can clear level 20. Levels are differentiated by virus counts, ranging from four at level 0 to 84 at levels 20 and higher. Above level 20, each level starts with 84 viruses, thus levels do not increase in difficulty past level 20. Much like Nintendo’s version of Tetris, the player may choose a level of difficulty to start, which is the game’s general speed and can be set to either Low, Medium, or High. Choosing the speed determines the game’s background color; the Low option making it dark green, Medium being blue, and High being gray. Two kinds of music can be chosen: Fever and Chill, with also the option of None.
The Game Boy version of the game is nearly identical to its NES counterpart. In keeping with the technical limitations of the device, the game features a playfield measuring eight-blocks by 15-blocks and viruses of black, white, and gray. In addition, levels increase in difficulty after level 20 and may be impossible. The Fever song was updated with a few extra musical notes and a slightly faster tempo.

| Developer(s) | Nintendo R&D1 |
| Publisher(s) | Nintendo |
| Designer(s) | Shigeru Miyamoto |
| Composer(s) | Hirokazu Tanaka. ex |
| Engine | Super Mario Bros. |
| Platform(s) | NES, SNES, Game Boy, Game Boy Advance, Nintendo GameCube (Japan Only), Nintendo DS |
| Release date(s) | JPNJuly 27, 1990 NAOctober, 1990 |
| Genre(s) | Puzzle game |
| Mode(s) | Single player, multiplayer |
| Rating(s) | ESRB: E (Everyone) (GBA, Wii) |


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